OXYMATRINE (AN INHIBITOR OF HSPA8) REDUCES BINDING OF VGF DERIVED BIOACTIVE PEPTIDE TLQP-21 TO THE SURFACE OF LIVE SH-SY5Y CELLS

Use of active site-targeting inhibitor is an effective approach leading to pharmacological inventions. Heat shock cognate protein A8 (HSPA8) has been found as a receptor VGF derived bioactive peptide TLQP-21 in SH-SY5Y cells. So, it was much interest carry out this study order observe whether Oxymatrine (OMTR), HSPA8, inhibits the binding surface intact, live The results confirmed, expected, that OMTR reduces cells, with strong conclusion cell model through HSPA8. inhibition efficacy potentiates its application drug targeting.